Preheat the air fryer to 300°F for 3 minutes.
In a large bowl, combine the Corn Chex, Rice Chex, mixed nuts, and mini pretzels.
Whisk the melted butter with the Worcestershire sauce, garlic powder, onion powder, and salt.
Pour the butter mixture over the cereal mix in thirds, gently tossing after each pour.
Add half the mix to the air fryer basket. Air fry at 300°F for 8 to 10 minutes, stirring every 3 minutes, until dry and golden.
Spread on a parchment-lined baking sheet to cool. Repeat with the remaining mix.
Cool completely, about 15 minutes, before serving or storing.