Preheat your oven to 350°F (175°C) and lightly grease a standard loaf pan or line it with parchment paper for easy cleanup.
In a large mixing bowl, combine ground beef, breadcrumbs, milk, ketchup, Worcestershire sauce, finely chopped onion, minced garlic, salt, pepper, and Italian seasoning.
Mix the ingredients gently with your hands or a spatula until just combined. Be careful not to overmix, as that can make the meatloaf dense.
Transfer the meat mixture into the prepared loaf pan. Shape it into a smooth loaf, pressing gently to remove any air pockets.
Spread a thin layer of ketchup on top if you like a glazed finish.
Bake in the preheated oven for 50 to 60 minutes, or until the internal temperature reaches 160°F (71°C).
Remove from the oven and let the meatloaf rest in the pan for 10 minutes before slicing. This helps it set and makes serving easier.
Slice and serve with your favorite sides like mashed potatoes, green beans, or roasted vegetables.