Cook the macaroni in salted boiling water until just under al dente, about 1 to 2 minutes shy of the package directions. Drain and set aside.
In a large oven safe skillet over medium heat, cook the chopped bacon until crispy, 6 to 8 minutes. Remove with a slotted spoon, leaving about 1 tablespoon of fat in the pan.
Add the butter to the bacon fat. Once melted, whisk in the flour and cook 1 to 2 minutes until light golden and nutty.
Pour in the Jack Daniel's and whisk vigorously. Let it simmer about 1 minute to cook off the alcohol and concentrate the flavor.
Slowly whisk in the warmed milk and cream. Add the Dijon, smoked paprika, garlic powder, onion powder, and cayenne. Simmer 4 to 5 minutes until thickened.
Lower the heat. Stir in the cheddar, gouda, and Parmesan a handful at a time until smooth. Season with salt and pepper.
Stir in the cooked pasta and most of the bacon until fully coated. Transfer to a buttered 9x13 baking dish if needed.
Combine the panko, melted butter, and Parmesan, then sprinkle over the top. Scatter the reserved bacon on top. Bake at 375°F for 20 to 25 minutes, until bubbly and golden. Broil 1 to 2 minutes for extra crunch.
Rest 5 to 10 minutes, garnish with parsley, and serve warm.