Spray your air fryer basket with cooking spray and set aside—reserve ¼ cup of flour in a small bowl for later use. In a small bowl, whisk together the 1/2 cup buttermilk and 1 large egg. Set aside. In a medium bowl, combine the remaining flour, 1/2 cup breadcrumbs, 1/2 teaspoon paprika, 1/2 teaspoon garlic powder, 1/2 teaspoon onion powder, 1/2 teaspoon kosher salt, 1/2 teaspoon Ground black pepper, and 1/4 teaspoon cayenne pepper together until well mixed.
To begin dredging, toss a chicken bite into the bowl of plain flour to evenly coat all sides. Dip the floured chicken piece into the egg mixture, then dip it into the breadcrumb mixture to coat evenly.
Place the 1 pound boneless skinless chicken breasts onto a large plate, and repeat until all the chicken is coated.
Line a layer of dredged chicken pieces onto the bottom of your oiled basket. Lightly spray the tops of the chicken pieces with cooking spray.
Set your air fryer temperature to 380 degrees F and set cook time for 10-14 minutes, tossing the chicken halfway through by shaking the basket or using tongs. Times may vary depending on your air fryer and chicken bite size.