Pat the tilapia fillets dry with a paper towel to remove any excess moisture.
In a shallow dish, combine the Parmesan cheese, breadcrumbs, garlic powder, paprika, and lemon zest.
In another shallow dish, whisk the egg until well-beaten.
Dip each tilapia fillet into the beaten egg, allowing any excess to drip off, then dredge it in the breadcrumb mixture, pressing lightly to coat evenly.
Heat olive oil in a large skillet over medium-high heat. Once hot, add the coated fillets and cook for about 3-4 minutes per side, or until golden brown and crispy.
Remove the tilapia from the skillet and let it rest briefly before serving. Pair with your favorite sides and enjoy your homemade Parmesan crusted tilapia!