Place chicken tenders in a bowl or zip-top bag. Pour buttermilk over the chicken and refrigerate for at least 30 minutes (or up to 4 hours) to tenderize and add moisture.
In a shallow dish, mix flour, paprika, garlic powder, onion powder, salt, black pepper, and cayenne pepper.
Remove chicken from buttermilk, letting excess drip off. Dredge each piece in the seasoned flour mixture, pressing gently to coat well.
Air fryer: Preheat to 400°F. Spray the basket lightly with cooking spray. Place tenders in a single layer, spray tops with cooking spray, and cook for 10–12 minutes, flipping halfway, until golden and cooked through.
Oven: Preheat to 425°F. Place tenders on a lined baking sheet. Spray with cooking spray and bake for 15–20 minutes, flipping halfway.
Enjoy your crispy chicken tenders with your favorite dipping sauces like honey mustard, BBQ, or ranch.