Make the cups: In a bowl, mix the panko, 2 cups of cheddar, the eggs, 1/2 teaspoon salt and 1/2 teaspoon pepper until the mixture holds together when squeezed.
Form: Spray 24 silicone mini muffin cups with cooking spray. Press a heaping tablespoon of the mixture into each cup, then make a well in the center with your thumb or the back of a teaspoon.
Make the filling: In a second bowl, stir together the cream cheese, bacon, diced jalapeños and the remaining salt and pepper.
Fill: Spoon about 2 teaspoons of filling into each cup. Top with a pinch of cheddar and a jalapeño round.
Air fry: Preheat the air fryer to 340°F. Air fry in batches for 8 to 10 minutes, until the edges are golden and the cheese is melted.
Cool: Let the bites rest in the cups for 3 to 5 minutes so they firm up, then remove them and serve warm.