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This Air Fryer Italian Grilled Cheese Sandwich stacks provolone, salami & prosciutto between crispy golden bread — a hot Italian sub melt ready in 13 minutes.

Air Fryer Italian Grilled Cheese Sandwich

5 from 4 votes
Author: Laurie Fleming
Prep Time: 5 minutes
Cook Time: 8 minutes
Total Time: 13 minutes
Servings: 2 Servings

Description

This Air Fryer Italian Grilled Cheese Sandwich layers creamy provolone, Genoa salami, hard salami, and prosciutto between crispy golden bread — all the flavor of an Italian sub in a hot, melty grilled cheese that's ready in just 13 minutes. It's the easiest cheesy lunch you'll make all week.

Ingredients 

  • 4 slices bread, Italian, ciabatta, sourdough, or focaccia
  • 2 tablespoons mayonnaise, or butter
  • 8 slices provolone cheese
  • 4 slices Genoa salami
  • 4 slices hard salami
  • 4 slices prosciutto

Instructions

  • Prep the bread. Spread mayonnaise or butter on one side of each slice of bread. This buttered side faces out and crisps in the air fryer.
  • Build the sandwiches. Place two slices mayo-side-down. On each, layer provolone, Genoa salami, prosciutto, hard salami, and a second slice of provolone. Top with the remaining bread, mayo-side-up.
  • Air fry. Place the sandwiches in the air fryer basket in a single layer (parchment or a spritz of cooking spray helps prevent sticking). Air fry at 400°F for 5 minutes.
  • Flip and finish. Carefully flip each sandwich with a spatula and air fry another 3 minutes, until the bread is deeply golden and the cheese is fully melted.
  • Rest and serve. Let the sandwiches rest for 1 minute, then slice and serve warm — with marinara for dipping, if you like.

Equipment

  • Air Fryer
  • Cooking Spray
  • Parchment Paper, optional

Notes

  • Preheat the air fryer for the crispiest results.
  • Secure loaded sandwiches with a toothpick or small trivet so the top slice doesn't lift in the airflow.
  • Don't overstuff — a tidy stack cooks more evenly and won't spill.
  • Room-temperature cheese melts faster and more evenly.
  • Cooking times vary slightly by air fryer model and bread thickness; add a minute if needed.

Nutrition

Serving: 1ServingCalories: 729kcalCarbohydrates: 29gProtein: 36gFat: 52gSaturated Fat: 21gPolyunsaturated Fat: 10gMonounsaturated Fat: 17gTrans Fat: 0.1gCholesterol: 97mgSodium: 1826mgPotassium: 354mgFiber: 2gSugar: 4gVitamin A: 685IUVitamin C: 0.1mgCalcium: 651mgIron: 3mg