In a large bowl, combine ground chicken with salt, pepper, garlic powder, onion powder, and paprika. Mix until well combined.
Use your hands or a spoon to shape the chicken mixture into bite-sized nuggets.
Place flour, beaten egg, and panko breadcrumbs in separate bowls. Coat each nugget in flour, dip in the egg, and then roll in panko breadcrumbs, ensuring an even coating.
Set the air fryer to 400°F (200°C) and let it preheat for a few minutes.
Arrange the coated nuggets in a single layer in the air fryer basket. Cook for 10-12 minutes, flipping halfway through, until golden brown and cooked through.
Ensure the internal temperature of the nuggets reaches 165°F (74°C). Adjust cooking time if needed.
Let the nuggets cool slightly before serving with your favorite dipping sauces. Enjoy your homemade, crispy chicken nuggets!