Pat the drumsticks dry with paper towels.
In a large bowl, whisk the olive oil, lemon juice, Cajun seasoning, garlic powder, paprika, cayenne, salt, and pepper.
Add the drumsticks and toss until evenly coated. Cover and refrigerate for 30 minutes to 12 hours. For the dry rub, skip the lemon juice and cook right away.
Preheat the air fryer to 375°F (190°C) for 3 to 5 minutes.
Blot excess marinade from the skin. Lightly spray the basket and arrange the drumsticks in a single layer, cooking in batches if needed.
Air fry for 25 to 30 minutes, flipping halfway, until the thickest part reads at least 165°F. For the most tender meat, cook to 175 to 185°F.
Optional: increase to 400°F for the last 2 to 3 minutes for extra-crispy skin.
Rest for 5 minutes. Serve with lemon wedges.