Prepare the Oven: Preheat your oven to 400°F (200°C). Line a baking sheet with parchment paper or lightly grease it.
Prepare the Shrimp: Clean the shrimp, leaving the tails on for easy handling. Pat them dry to remove any excess moisture.
Season the Flour: In a shallow dish, mix the flour with salt, pepper, and garlic powder.
Beat the Eggs: In another shallow dish, lightly beat the eggs.
Panko Breadcrumbs: Place the Panko breadcrumbs in a third shallow dish.
Bread the Shrimp: Dredge each shrimp first in the seasoned flour, then dip into the beaten eggs, and finally coat thoroughly with Panko breadcrumbs.
Arrange on Baking Sheet: Place the breaded shrimp in a single layer on the prepared baking sheet. Lightly spray or brush the shrimp with cooking spray or olive oil.
Bake: Bake in the preheated oven for about 10-15 minutes, or until the shrimp are golden brown and cooked through. For extra crispiness, broil for the last 1-2 minutes.
Serve Hot: Serve the shrimp immediately, optionally with lemon wedges and your choice of dipping sauce.