Preheat your Blackstone griddle top to medium heat.
Combine the Chex cereal, pretzels, nuts, and crackers in a large mixing bowl. Mix well to ensure an even distribution of ingredients. In a small saucepan or microwave-safe bowl, melt the butter. Add the Worcestershire sauce, garlic powder, onion powder, salt, and any optional seasonings. Stir well to combine.
Pour the butter mixture over the Chex cereal mixture. Stir gently with a spatula or wooden spoon until all the ingredients are evenly coated.
Transfer the Chex Mix mixture to the preheated Blackstone griddle. Spread it out in an even layer, ensuring it covers the cooking surface. Cook the Chex Mix on the griddle, stirring frequently to prevent burning and ensure even cooking. Cook for about 10-15 minutes or until the mix is toasted and crispy.
Once cooked, remove the Chex Mix from the griddle and let it cool completely. The mix will continue to crisp up as it cools. Once cooled, transfer the Chex Mix to an airtight container for storage or serve immediately as a delicious snack.