Combine the ground bison, breadcrumbs, Parmesan cheese, egg, parsley, garlic, salt, and black pepper in a big bowl. Mix well to combine.
Roll the mixture into small meatballs about 1 inch in diameter using your hands. Preheat the air fryer, to 375 degrees F, for 3-5 minutes using the air frying setting.
Spray the air fryer basket with cooking spray, or brush the basket with olive oil. Place the meatballs in the basket in a single layer, making sure they don't touch each other. Cook the meatballs for 10-12 minutes, shaking the basket halfway through the cooking time to ensure they cook evenly.
Remove when the internal temperature reaches 160 degrees F, placing a meat thtmotmer into the center of the bison meatball with a meat thermometer.
Once the meatballs are cooked and browned on the outside, remove them from the air fryer basket using tongs or a spatula. Let the meatballs cool for a few minutes before serving.