In a small bowl, mix the Frank’s Red Hot Sauce and water.
In a medium-sized bowl, mix the flour, cayenne, salt, onion powder, black pepper, paprika, and garlic powder.
Coat the chicken breast in the flour mixture, then into the hot sauce mixture, and back into the flour mixture. Use your hands to make sure that that flour mixture covers the entire chicken breast. Repeat until all of the chicken is coated.
Spray your air fryer basket with cooking spray, and then preheat the air fryer to 370 degrees F, air fryer setting for 5 minutes.
Add your chicken breast. Use cooking spray GENEROUSLY coat the top of the chicken so the entire flour coating is coated. This will help your chicken crisp up. Set the timer for 7 minutes, then use a pair of tongs, flip the chicken, spray again, coating the flour mixture, and set the timer for another 7-10 minutes.
Check the internal temperature of the chicken before removing it. The internal temperature needs to be 165 degrees F.
To Serve: Spread the mayonnaise on the bottom bun, and then place the cooked chicken breast onto a hamburger bun, top with pickles, lettuce, and tomato.
Plate, serve, and enjoy!